par Blum, David ;Wu, Ying;Nissou, Marie-France;Arnaud, Séverine;Benabid, Alim-Louis;Verna, Jean-Marc
Référence Brain research, 751, 1, page (139-142)
Publication Publié, 1997-03
Référence Brain research, 751, 1, page (139-142)
Publication Publié, 1997-03
Article révisé par les pairs
Résumé : | p53, Bax and Bcl-xL proteins have been implicated in apoptotic neuronal cell death. We have investigated whether those proteins are involved in 6-OHDA-induced PC12 cell death. After a 24-h exposure to the neurotoxin (100 microM), morphological evidence for apoptosis was observed in PC12 cells. Up-regulation of p53 and Bax proteins was demonstrated 4 and 6 h, respectively, after 6-OHDA treatment; in contrast, no change in Bcl-xL levels was found. These findings suggest that p53 and Bax could be relevant markers of neuronal apoptosis as previously described in kainic acid- or ischemia-induced neuronal cell death and may participate to neuronal degeneration in Parkinson's disease. |