Résumé : The enantiomers of the Si/Ge analogues cyclohexyl(hydroxymethyl)phenyl-(2-piperidinoethyl)silane and -germane and their methiodides were synthesized and investigated with respect to their affinities at muscarinic M1, M2, and M3 receptors. The compounds displayed pronounced stereoselective antimuscarinic action, the (R)-enantiomers being more potent than the corresponding (S)-antipodes. The receptor affinities of the respective Si/Ge analogues were found to be very similar, indicating a strongly pronounced Si/Ge bioisosterism.