par Willems, Lucas
;Gegonne, A.;Chen, G;Burny, Arsène
;Kettmann, Richard
;Ghysdael, Jacques 
Référence EMBO journal, 6, 11, page (3385-3389)
Publication Publié, 1987-11




Référence EMBO journal, 6, 11, page (3385-3389)
Publication Publié, 1987-11
Article révisé par les pairs
Résumé : | Recombinant Moloney murine retroviruses containing the BLV post-envelope long open reading frame were constructed and transfected into the psi 2 packaging cell line. They were shown to encode and to express a 34-kd protein able to transactivate the BLV long terminal repeat-directed gene expression in the respective transfected cells. These data demonstrate that the BLV X-LOR gene encodes a p34 transactivator product. Furthermore, the different cell lines produced infectious recombinant retroviruses capable of transferring X-LOR genes into recipient cells. The availability of the BLV transactivator protein should allow us to understand the role of the transactivator protein in BLV-induced leukemogenesis. |