par Désir, Daniel 
;Van Cauter, Eve ;L'Hermite, Marc ;Refetoff, Samuel ;Jadot, Claude ;Caufriez, Anne ;Copinschi, G.. ;Robyn, Claude
Référence The Journal of clinical endocrinology and metabolism, 55, 5, page (849-857)
Publication Publié, 1982-11
;Van Cauter, Eve ;L'Hermite, Marc ;Refetoff, Samuel ;Jadot, Claude ;Caufriez, Anne ;Copinschi, G.. ;Robyn, Claude Référence The Journal of clinical endocrinology and metabolism, 55, 5, page (849-857)
Publication Publié, 1982-11
Article révisé par les pairs
| Résumé : | The 24-h profile of plasma PRL was obtained by blood sampling at 15-min intervals, and sleep was polygraphically recorded in five normal males, under basal conditions, 1, 11, and 21 days after they travelled from Brussels to Chicago by jet and 1, 11, and 21 days after the return flight. The time difference between Brussels and Chicago was 7 h. Fifteen months later, two of the volunteers were submitted to blood sampling and sleep recording for 48 h after they underwent 33 h of sleep deprivation, mimicking the conditions of the eastward shift without the actual travel. Under basal conditions, the 24-h PRL pattern was bimodal, with a late afternoon elevation and a major nocturnal rise starting shortly after sleep onset and culminating in a midsleep acrophase. Serum PRL levels remained high until awakening, followed by a rapid decline. The 24-h mean PRL level, the ratio of the sleep mean to the wake mean, the value of the nocturnal acrophase, and the number of secretory spikes per 24-h span were not affected by “jet lag” or sleep deprivation, suggesting that these perturbations do not induce alterations in the amount of PRL secreted, even though they were associated with significant disruptions of sleep. One day after the westward flight, a brief elevation in PRL concentration was observed during wakefulness, at the time of the anticipated sleep-associated increase according to Brussels time (anamnestic peak), and the nocturnal PRL acrophase occurred earlier in sleep, with declining levels throughout the rest of the night. Eleven and 21 days after arrival in Chicago, the PRL secretory pattern during sleep had normalized, but anamnestic peaks were still observed. One day after eastward travel, the sleep-related increase in PRL levels was very gradual, reaching its peak only at the anticipated onset of sleep according to Chicago time, and PRL concentrations declined less abruptly after awakening. Full return to the original secretory pattern was observed 11 and 21 days after arrival in Brussels. The 24-h PRL patterns obtained after sleep deprivation were similar to those observed immediately after eastward flight. These results indicate that the nighttime rise of PRL is not solely dependent upon sleep, but also possesses an intrinsic circadian rhythm |
