par Hampe, Christiane Susanne;Petrosini, Laura;De Bartolo, Paola;Caporali, Paola;Cutuli, Debora;Laricchiuta, Daniela;Foti, Francesca;Radtke, Jared JR;Vidova, Veronika;Honnorat, Jerome;Manto, Mario 
Référence Orphanet journal of rare diseases, 8, page (82)
Publication Publié, 2013
Référence Orphanet journal of rare diseases, 8, page (82)
Publication Publié, 2013
Article révisé par les pairs
| Résumé : | Stiff Person Syndrome (SPS) is a rare autoimmune movement disorder characterized by the presence of autoantibodies specific to the smaller isoform of glutamate decarboxylase (GAD65). A pathological role of these antibodies has been suggested by their capacity to inhibit GAD65 enzyme activity and by the observation that rats receiving cerebellar injections of GAD65Ab showed cerebellar motor hyperexcitability. To assess the effect of epitope-specific GAD65Ab on cognitive and motor functions, we conducted behavioral experiments in rats that received cerebellar injections with two distinct monoclonal GAD65Ab (b96.11 and b78). |
