Résumé : OBJECTIVE:To identify patterns of perception of front-of-pack (FOP) nutrition labels and determine dietary, lifestyle and health profiles related to such patterns.DESIGN:Cross-sectional.PARTICIPANTS/SETTING:28,952 French adults participating in the web-based Nutrinet-Santé cohort.OUTCOME MEASURES:Perception was measured using indicators of understanding and acceptability for three simple FOP labels ("green tick", the logo of the French Nutrition and Health Program and "simple traffic lights" (STL)), and two detailed FOP formats ("multiple traffic lights" (MTL) and "color range" logo (CR)), placed on ready-to-eat soup packages. Dietary intake data were collected using three web-based 24 h records.STATISTICAL ANALYSES:Associations of perception patterns with individual characteristics, including diet, lifestyle and health status, were examined using analysis of covariance and logistic regression, adjusted for socio-demographic and economic factors.RESULTS:No clear trend emerged concerning differences in dietary intake between perception groups. Low physical activity and obesity were more frequent in the 'favorable to STL' group (respectively, 20.7% and 10.7%). The 'favorable to MTL' group included the highest percentage of individuals who declared type 2 diabetes (2.2%). Persons with hypertension were proportionally more numerous in the 'favorable to MTL' and the 'favorable to CR logo' groups (respectively, 9.5% and 9.3%).CONCLUSIONS:After adjustment for socio-demographic and economic factors, no FOP label stood out as being more suitable than another for reaching populations with poor diet. However, both STL and MTL may be most appropriate for increasing awareness of healthy eating among groups at higher risk of nutrition-related chronic diseases.