par Higuet, Nathalie;Brohée, Dany
Référence International journal of immunopharmacology, 14, 6, page (1107-1111)
Publication Publié, 1992-08
Référence International journal of immunopharmacology, 14, 6, page (1107-1111)
Publication Publié, 1992-08
Article révisé par les pairs
Résumé : | Dipyridamole inhibits, by 50% at 10(-6) M and 100% at 10(-5) M, the incorporation of tritiated thymidine by lymphocytes stimulated with 1 microgram/ml phytohaemagglutinin A for 72 h. At the latter concentration, a clinically relevant one, dipyridamole fails to inhibit lymphocyte proliferation and expression of the cell surface stimulation markers, CD25 and HLA-DR, or differential regulation of the CD45 -RA and -RO isoforms, as determined by single laser two-colour flow-cytometry. No significant immunodepressant effect of dipyridamole can be demonstrated in vitro. |