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From MIN model to ordinary differential equations: in Special Issue: 4th Integrative Bioinformatics Workshop, Gent, Belgium

par Yartseva, Anastasia;Devillers, Raymond ;Klaudel, Hanna;Képès, François
Référence Journal of integrative bioinformatics, 4, 3, page (1-12), 61
Publication Publié, 2007-10

Article révisé par les pairs

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Résumé :

Biological interaction networks can be modeled using the Modular Interaction Network (MIN) formalism, which provides an intermediary modeling level between the biological and mathematical ones. MIN focuses on a simple but structured and versatile representation of biological knowledge, without targeting a particular analysis or simulation technique. In this paper, we propose a translation procedure which, starting from a MIN specification of a biological system, generates its representation in ordinary differential equations (ODEs) allowing to study the dynamics of the system. The translation is illustrated on a classical benchmark: the lambda phage genetic switch.