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Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON-TB Gold In-tube.

par Wyndham-Thomas, Chloe ;Dirix, Violette ;Schepers, Kinda ;Martin, Charlotte ;Hildebrand, Marc;Goffard, Jean-Christophe ;Domont, Fanny;Libin, Myriam ;Loyens, Marc;Locht, Camille ;Van Vooren, Jean-Paul ;Mascart, Françoise
Référence BMC infectious diseases, 15, page (59)
Publication Publié, 2015

Article révisé par les pairs

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Résumé :

The screening and treatment of latent tuberculosis (TB) infection reduces the risk of progression to active disease and is currently recommended for HIV-infected patients. The aim of this study is to evaluate, in a low TB incidence setting, the potential contribution of an interferon-gamma release assay in response to the mycobacterial latency antigen Heparin-Binding Haemagglutinin (HBHA-IGRA), to the detection of Mycobacterium tuberculosis infection in HIV-infected patients.