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Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

par Goovaerts, Odin;Jennes, Wim;Massinga-Loembé, Marguerite;Ondoa, Pascale;Ceulemans, Ann;Vereecken, Christian ;Worodria, William;Mayanja-Kizza, Harriet;Colebunders, R;Kestens, L.;Mascart, Françoise ;TB-IRIS Study Group, TBSG; [et al.]
Référence PloS one, 10, 7, page (e0133924)
Publication Publié, 2015

Article révisé par les pairs

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Résumé :

Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory complication in HIV-TB co-infected patients receiving antiretroviral therapy (ART). The role of disturbed T cell reconstitution in TB-IRIS is not well understood. We investigated T cell activation and maturation profiles in patients who developed TB-IRIS at different intervals during ART.