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Genomic aberrations in young and elderly  breast cancer patients.

par Abdel Azim, Hatem Hamdy ;Nguyen, Bastien ;Brohée, Sylvain ;Zoppoli, Gabriele;Sotiriou, Christos
Référence BMC medicine, 13, page (266)
Publication Publié, 2015

Article révisé par les pairs

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Résumé :

Age at breast cancer diagnosis is a known prognostic factor. Previously, several groups including ours have shown that young age at diagnosis is associated with higher prevalence of basal-like tumors and aggressive tumor phenotypes. Yet the impact of age at diagnosis on the genomic landscape of breast cancer remains unclear. In this study, we examined the pattern of somatic mutations, chromosomal copy number variations (CNVs) and transcriptomic profiles in young and elderly breast cancer patients.