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Ichtyose linéaire circonflexe de comel: traitement par ro 10-9359. Étude en microscopie électronique

par Mathys, Claire ;De Dobbeleer, Gilbert ;Ledoux, Marguerite ;Achten, Georges
Référence Dermatologica, 171, 4, page (283-290)
Publication Publié, 1985

Article révisé par les pairs

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Résumé :

The authors show the noteworthy efficacy of the aromatic retinoid Ro 10-9359 in the treatment of ichthyosis linearis circumflexa. The initial dose was 1 mg/kg daily; later on, the maintenance dose was 0.3 mg/kg daily. Ultrastructurally, transitional cells were observed between the granular and the horny layer. After treatment, large perinuclear pseudovacuoles appeared, as well as numerous microvilli.