par Rochus, L.;Sterckx, Gérard 
;Reuse, Joannes
Référence Archives internationales de pharmacodynamie et de thérapie, 206, 2, page (399-402)
Publication Publié, 1973
;Reuse, Joannes Référence Archives internationales de pharmacodynamie et de thérapie, 206, 2, page (399-402)
Publication Publié, 1973
Article révisé par les pairs
| Résumé : | Studies were initiated to determine whether morphine, dextromoramide and fentanyl in vivo would alter phospholipid metabolism in rat brain tissue. The narcotic drugs stimulated the incorporation of 32P orthophosphate (32Pi) into cerebral cortex, white matter, hypothalamus, vermis and cerebellar cortex phospholipids 24-50% (P < 0.1) at 16 hr and 32-50% (P < 0.05) at 42 hr after 32Pi. A stimulation of incorporation of 32Pi ranging from 21-62% occurred at 16 hr in phospholipid fractions, separated according to Dawson. Previous results obtained by Mule on the guinea pig were confirmed. |
