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Variations of the proliferative activity of leukemic myeloblasts related to the stage of the disease

par Stryckmans, Pierre ;Debusscher, Louise ;Peltzer, T.;Socquet, Mireille
Référence Blood cells, 1, 1, page (239-251)
Publication Publié, 1975

Article révisé par les pairs

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Résumé :

The proliferative activity of bone marrow myeloblasts was studied by means of tritiated thymidine (3HTdR) and autoradiography. Twenty six patients in the active phase or in complete remission of acute myeloblastic leukemia (AML), 16 in relapse or in remission of chronic leukemia (CML) and 10 hematologically normal reference patients have been investigated. In AML, the 3HTdR labeling index of the myeloblasts returned and remained in the range of normal values during complete remission in the 6 patients examined. In CML, the 3HTdR labeling index of the myeloblasts but not of more mature myeloid cells was normal when the white blood count (WBC) was below 20000/mm3 but was found to decrease when the WBC increased above 20000/mm3. It is concluded that the low labeling indices of myeloblasts during active AML and CML is not an indication of the degree of malignancy of these cells but rather the expression of regulatory mechanisms probably operating on the normal myeloblast and persisting during leukemia.