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Effects of cortisone on acid, pepsin, sulfated polysaccharides and glycoprotein secretion by the mucosa of denervated fundic pouches of dogs

par Bremen, Jacques ;Ley, Robert ;Woussen Colle, Marie-Claire ;Verbeustel, Suzanne ;De Graee, J.
Référence Digestion, 4, 2, page (81-91)
Publication Publié, 1971

Article révisé par les pairs

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Résumé :

The effects of acute and chronic administra- tion of corticosteroids were studied on the fundic secre- tion of 10 Heidenhain pouch dogs. Acid, pepsin and chondroitin-4-sulfate secretion is increased during chron- ic administration. There is a latent time interval before these changes become apparent. Secretions of total and acidic glycoproteins from the visible mucus are increased during chronic but not after acute corticosteroid treat- ment. The ability of the peptic and mucous cells to synthesize pepsin, chondroItin-4-sulfate and glycoproteins is not decreased but rather increased during prolonged cortisone treatment. © 1971 S. Karger AG, Basel.