Résumé : Presence of chondroitin-4-sulfate has been demonstrated in the gastric fundic juice of the dog. It is secreted by the chief peptic cells. Chondroitin sulfate-like material was also observed in the pyloric cells of the same animal. In the dog. chondroitin-4-sulfate secretion by the fundus is increased during cholinergic stimulation but not during stimulation by histamine or a gastrin-like pentapeptide. So far no sulfaled polysaccharides has ever been isolated from gastric juices of other species. Histochemically, such a compound has also been demonstrated in the chief and pyloric cells of the cat and in mucous neck cells of the monkey. © 1969 S. Karger AG, Basel.