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Parenteral verabreichte mittelkettige triglyzeride induzieren veränderungen im carnitin-stoffwechsel

par Rössle, Claudia;Carpentier, Yvon ;Richelle, Myriam ;Dahlan, Winai ;D'Attellis, N.P.;Elwyn, David;Stehle, Peter;Furst, Peter
Référence Transfusion medicine and hemotherapy, 18, 4, page (167-171)
Publication Publié, 1991

Article révisé par les pairs

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Résumé :

Medium-chain triglycerides are generally assumed to be metabolized independently of carnitine. The effects of infusing medium-chain triglycerides on plasma concentrations of carnitine derivatives and β-hydroxybutyrate were studied in four healthy male adults. Glucose and amino acids were infused alone for three hours, then continued for another 5.5 hours together with a lipid emulsion containing only long-chain triglycerides or a mixture of medium-chain and long-chain triglycerides (50:50; w/w). During the fat-free infusion, the concentration of free carnitine rose, while the level of acylcarnitines decreased. Infusion of the mixed emulsion over 5.5 hours reduced free carnitine to lower values (32.4 ± 4.7 μmol/L) than long-chain triglycerides infusion (44.4 ± 2.7 μmol/L). By contrast, the plasma concentrations of short-chain acylcarnitines (12.1 ± 3.3 vs. 5.4 ± 1.9μmol/L: p<0.01) and of (5-hydroxybutyrate (93 ± 32 vs. 47 ± 14 μmol/L: p<0.01) became significantly higher with the mixed emulsion than with long-chain triglycerides. These findings suggest that oxidation of medium-chain fatty acids is to some extent carnitine-dependent, whether or not transport into mitochondria is carnitine-mediated. © 1991 S. Karger GmbH, Freiburg.