par Hallin, Marie ;Deplano, Ariane ;Struelens, Marc
Référence New Frontiers of Molecular Epidemiology of Infectious Diseases, Springer Netherlands, page (9-25)
Publication Publié, 2011-06
Partie d'ouvrage collectif
Résumé : Molecular typing is nowadays an integral part of the public health microbiology toolbox. It indexes subspecies genotypic or phenotypic characters to estimate the genetic relatedness of microbial isolates and infer from it their probability of belonging to the same chain of transmission. Typing is used both to investigate outbreaks and enhance the resolution of disease surveillance at different population levels: (i) locally, in hospitals or the community, by clinical or public health laboratories; (ii) nationally, by reference laboratories or (iii) globally, through international surveillance networks. This chapter provides an overview of currently available and emerging technologies for typing human bacterial pathogens, discusses their suitability to different levels of use and reviews examples of integrated typing in advanced surveillance systems.