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The european stroke prevention study: Results according to sex

par Sivenius, Juhani;Laakso, Markku;Penttilä, Ilkka Matti;Smets, Philippe ;Lowenthal, Armand ;Riekkinen, Paavo Johannes P.
Référence Neurology, 41, 8, page (1189-1192)
Publication Publié, 1991

Article révisé par les pairs

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Résumé :

The European Stroke Prevention Study was a multicenter trial comparing the effect of a combination of 75 mg dipyridamole and 33 mg acetylsalicylic acid tid with placebo in the prevention of stroke or death after one or more attacks of recent transient ischemic attack or stroke of atherothrombotic origin. From the 2,500 patients in the intention-to-treat analysis, the proportion of women was 42%, and from the 1,861 patients in the explanatory analysis it was 44%. The endpoint incidence was significantly higher in men than in women. The endpoint reduction was statistically significant in men in both types of analyses with total endpoints (stroke or death) and in the risk of stroke, while in women it was statistically significant only in the intention-to-treat analysis with total endpoints. However, there was a marked percentage reduction of endpoints in both men and women in explanatory analysis. The risk reduction of strokes was 49% for men and 41% for women, and the reduction of total endpoints was 39% in men and 30%nt; in women. Thus, antiplatelet therapy is effective in the prevention of stroke or death in both sexes. © 1991 American Academy of Neurology.