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Cognitive Improvement of Attention and Inhibition in the Late Afternoon in Children with Attention-Deficit Hyperactivity Disorder (ADHD) Treated with Osmotic-Release Oral System Methylphenidate

par Slama, Hichem ;Fery, Patrick ;Verheulpen, Denis ;Vanzeveren, Nathalie ;Van Bogaert, Patrick
Référence Journal of child neurology, 30, 8, page (1000-1009)
Publication Publié, 2015-07

Article révisé par les pairs

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Résumé :

Long-acting medications have been developed and approved for use in the treatment of attention-deficit hyperactivity disorder (ADHD). These compounds are intended to optimize and maintain symptoms control throughout the day. We tested prolonged effects of osmotic-release oral system methylphenidate on both attention and inhibition, in the late afternoon. A double-blind, randomized, placebo-controlled study was conducted in 36 boys (7-12 years) with ADHD and 40 typically developing children. The ADHD children received an individualized dose of placebo or osmotic-release oral system methylphenidate. They were tested about 8 hours after taking with 2 continuous performance tests (continuous performance test-X [CPT-X] and continuous performance test-AX [CPT-AX]) and a counting Stroop. A positive effect of osmotic-release oral system methylphenidate was present in CPT-AX with faster and less variable reaction times under osmotic-release oral system methylphenidate than under placebo, and no difference with typically developing children. In the counting Stroop, we found a decreased interference with osmotic-release oral system methylphenidate but no difference between children with ADHD under placebo and typically developing children.