par Verborgh, Christian;Camu, Frédéric
Référence European Journal of Clinical Pharmacology, 38, 5, page (437-442)
Publication Publié, 1990-05
Référence European Journal of Clinical Pharmacology, 38, 5, page (437-442)
Publication Publié, 1990-05
Article révisé par les pairs
Résumé : | A double-blind, placebo-controlled study has been made of the analgesic and respiratory effects of constant rate infusions of meptazinol and morphine in 30 patients after abdominal surgery. Group I received meptazinol, loading dose 50 mg followed by i.v. infusion 0.5 mg · kg-1 · h-1, Group II received morphine, loading dose 5 mg and then an infusion of 0.05 mg · kg-1 · h-1, and Group III received saline. After recovery from inhalation anaesthesia (without opiates or a local anaesthetic) pain relief and chemoreceptor carbon dioxide tolerance were assessed before and at various times after starting the analgesic infusion. A similar degree of pain relief was found after 10 min in Groups I and II, which lasted until the end of observation period (20 h). Heart rate and systolic and diastolic blood pressures were lower in Group II than in Groups I and III, and respiratory rate fell in Groups I and II. After 6 h arterial carbon dioxide tensions (PaCO2) became significantly higher in Group II than Group III. The maximum percentage fall in mean tidal volume (VT) and expired minute volume (0VE) from the preinjection values was significant in Groups I and II. End-tidal carbon-dioxide (PETCO2) and PaCO2 were significantly higher after 20 h of infusion in Group II compared to Group I. The slope of 0VE/PETCO2 ( |