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Rapid regression of Graves' disease ophthalmopathy in the presence of lymphocytosis, cervical micropolyadenopathy and transitory depression of immunoglobulins. Activation of a tolerogenic axis involving the thyroid gland, thymus and lymph nodes (French)

par Mahaux, Jacques ;Chamla Soumenkoff, J.;Levin, Stuart
Référence Annales d'Endocrinologie, 35, 2, page (204-212)
Publication Publié, 1974

Article révisé par les pairs

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Résumé :

A bout of hyperthyroidism with ophthalmopathy was followed by the development of a cervical polymicroadenopathy, lymphocytosis and a progressive depression of immunoglobulins. The thyro thymic lymphatic migration was accelerated. Under neomercazol treatment, the modified thyroproteins which are brought to the thymus seemed to exercise an efficient tolerogenic influence. The paracortical zones, 'thymodependent', of the lymphoid nodules were colonized by a particular population of T lymphocytes. Antibody producing plasmatocytes were not detected. The increase of the thyroid contribution and its qualitative modifications mobilized homeostatic axis thyroid thymus lymphoid nodules, whose adjusted tolerogenic power appeared to condition the utilization of thyroid products for physiological and metabolic purposes.