par Weibel, Laurence ;Turek, Fred ;Mocaer, Elisabeth;Van Reeth, Olivier
Référence Brain research, 880, 1-2, page (207-211)
Publication Publié, 2000-10
Référence Brain research, 880, 1-2, page (207-211)
Publication Publié, 2000-10
Article révisé par les pairs
Résumé : | Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by ~25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging. Copyright (C) 2000 Elsevier Science B.V. |