par Vaes, Peter P.H.;Brouwez, M.;Van Hille, Guy
Référence Acta oto-rhino-laryngologica Belgica, 29, 3, page (553-557)
Publication Publié, 1975
Article révisé par les pairs
Résumé : A study of 41 patients with multiple sclerosis where the evolution was followed for at least 3 years permitted a certain systematic analysis of the vestibular apparatus. An exact program consisting of tracing of spontaneous nystagmus and caloric stimulation of both labyrinths, with reference to latency period, frequency, total duration and number of nystagmus, amplitude of the fast phase and vestibulospinal reactions permitted a follow up of the evolution and response to ACTH therapy. A study of the spontaneous nystagmus showed that the ocular movement will be altered by a horizontal nystagmus, which becomes transformed to multiple and subsequently to dissociated nystagmus by involvement of the fasciculus longitudinalis posterior. Regression of the nystagmus was seen in some cases but without a definite relation to treatment. Vestibular examination mostly shows a normal (42%) or relatively hyporeflective (35%) response at the onset of follow up. At the end of the disease a directional preference of the nystagmus and hyporeflexia become important, mostly corresponding to dissociated nystagmus. The study also showed that stimulation of the adrenals, which leads to immediate clinical improvement, has little effect on the oculovestibular system.