par Blum, David ;Martire, Alberto;Burnouf, Sylvie;Sablonnière, Bernard;Krystkowiak, Pierre;Ledent, Catherine ;Lopes, Luísa Vaqueiro;Popoli, Patrizia
Référence Adenosine: A Key Link between Metabolism and Brain Activity, Springer New York, page (409-434)
Publication Publié, 2013-11
Référence Adenosine: A Key Link between Metabolism and Brain Activity, Springer New York, page (409-434)
Publication Publié, 2013-11
Partie d'ouvrage collectif
Résumé : | Huntington's disease is a devastating hereditary neurodegenerative disorder caused by CAG mutation within the IT15 gene encoding Huntingtin protein. Even though mutant and normal Huntingtin are ubiquitously expressed, the degenerative processes primarily occur within the striatum and particularly hit the GABAergic enkephalin neuronal subpopulation of medium spiny neurons particularly enriched with adenosine A |