Résumé : The effect of variations of the fundamental constants on the thermonuclear rate of the triple alpha reaction, 4He(α α λ )12C, that bridges the gap between 4He and 12C is investigated. We have followed the evolution of 15 and 60 M ⊙ zero metallicity stellar models, up to the end of core helium burning. They are assumed to be representative of the first (Population IH) stars. The calculated oxygen and carbon abundances resulting from helium burning can then be used to constrain the variation of the fundamental constants. © 2010 American Institute of Physics.