par Fontaine, Jeanine ;Reuse, Joannes
Référence Journal de pharmacologie, 7, 2, page (147-159)
Publication Publié, 1976
Article révisé par les pairs
Résumé : The effects of procaine (PC) and procainamide (PCA) have been studied on the isolated Guinea Pig ileum and compared to those previously described with metoclopramide (MCP). PC and PCA have a direct stimulating effect on the muscle. In contrast to MCP, no cholinergic activity was observed. Like MCP, but at higher doses, PC and PCA have an antiserotonin activity of the competitive noncompetitive type. PC and PCA reduce the responses of the ileum to coaxial stimulation, PC is more active than PCA. PC, but not PCA, inhibits the responses to acetylcholine (AC) in a competitive manner. PCA is able to increase the maximum response of the ileum to AC. The PCA effect on the AC curves suggests the same kind of potentiation than that observed previously by us with MCP which appears however to be much more potent.