par Brauman, Henri ;Dupont, Etienne ;Valsamis, José
Référence Pathologie et biologie, 26, 6, page (313-316)
Publication Publié, 1978
Article révisé par les pairs
Résumé : Plasma β2m has been measured frequently during long term follow up of kidney transplanted outpatients. The ratio of β2m/log creatinine was abnormally high in 15 patients of this series with a symptomatic hepatitis, independent of any modification of immunodepressive drug administration schedule (azathioprine and corticoids). The true effect of azathioprine could not be isolated whereas corticotherapy clearly modified the β2m/creatinine ratio: an increase of dosage for rejection resulted in a fall of the ratio, whereas fast reduction increased the ratio by acting essentially on circulating β2m level (12 cases). The β2m/creatinine ratio was normal or occasionally diminished in the 22 patients having an uneventful clinical course. Six of the patients showed mixed effects of corticoids on hepatitis and in 7 cases the complications were so numerous that a good analysis of the data was not possible.