Article révisé par les pairs
Résumé : The macro- and microscopic aspects of the development of the skeleton of the mouse hindlimb were analysed by techniques previously described for the forelimb. Macroscopic aspects in embryos aged 13.5 to 18 days were studied by means of double staining with alcian blue-alizarin. Four successive stages in the skeletal differentiation were distinguished microscopically using Masson's trichrome staining, autoradiography with S35 and selective staining of cartilage with alcian blue and toluidine blue. Serial sections of hindlimb buds of embryos from 11 to 15 days revealed the progress of skeletogenesis and provided criteria of normality to be used in subsequent explorations of teratogenicity in the mouse.