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Preoptic hypnogenic area and reticular activating system

par Bremer, Frédéric
Référence Archives Italiennes de Biologie, 111, 2, page (85-111)
Publication Publié, 1973

Article révisé par les pairs

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Résumé :

The stimulation, in the encephale isole cat, of the basal preoptic hypnogenic area by brief electrical pulses evokes bilaterally an extracellular positive (P) field potential of 20 to 60 msec duration in the brain stem and thalamic activating ascending reticular system. The properties of this P wave have led to it being considered as the extracellular and abbreviated counterpart of an hyperpolarizing postsynaptic inhibitory process which, by the functional depression it exerts on the arousal system, would be instrumental in the induction and maintenance of synchronized sleep. The positive field potential response of the reticular system shows the same recruiting build up and amplitude modulation, and the same sensitivity to amphetamine and to barbiturates, as the cortical potential of diffuse distribution which is evoked simultaneously. It is resistant to strychnine and picrotoxin. Preoptic stimulation exerts, within a 100 msec interval, a strong suppressive effect on the excitatory response evoked in the centromedian nucleus by a mesencephalic reticular testing shock. On the other hand, the application of the latter as a conditioning stimulus results in a marked increase of the amplitude of the P wave response of the centromedian nucleus to a testing preoptic shock. A negative feedback interpretation of this interaction is suggested. No clear evidence of a tonic functioning of the preoptic hypnogenic structure could be found in experiments involving the production of small bilateral lesions in the basal preoptic area in the encephale isole cat. Reasons limiting the interpretation of this negative result are given. The functional significance, on the basis of experimental data, of the diffuse cortical synchronization produced by the low frequency stimulation of the basal preoptic area and of other hypnogenic structures is discussed.