par Ginsberg, Francis;Famaey, Jean Pierre 
Référence Current therapeutic research, 28, 5 I, page (622-629)
Publication Publié, 1980
Référence Current therapeutic research, 28, 5 I, page (622-629)
Publication Publié, 1980
Article révisé par les pairs
| Résumé : | In an 8-week double-blind study involving 50 patients with cervical or lumbar osteoarthritis, tolmetin and naproxen were compared for efficacy and tolerability in the treatment of the symptoms of the disease. Study drugs were administered on a b.i.d. schedule: 800 mg of tolmetin or 500 mg of naproxen. Passive pain, pain on pressure and functional parameters (flexion, extension and rotation) were evaluated at baseline and at weeks 2, 4 and 8. Results showed that patients in both groups were significantly improved in all parameters and that tolmetin was significantly superior to naproxen in both pain parameters. The superiority of tolmetin over naproxen in functional parameters was not statistically significant. Tolmetin acted rapidly; at 2 weeks 75% of the tolmetin patients, as compared with only 42% of the naproxen patients, reported efficacy greater than that of their previous therapy. Two patients in the naproxen group discontinued because of gastrointestinal symptoms. While both study drugs were effective, tolmetin appeared to be superior to naproxen in pain relief; the drugs were equivalent in influencing motility parameters. |
