par Vanhoof, Raymond;Clumeck, Nathan 
;Demol, Pascale ;Vanderlinden, M P;Butzler, Jean-Paul ;Yourassowsky, Eugène
Référence Current medical research and opinion, 5, S2, page (34-37)
Publication Publié, 1978
;Demol, Pascale ;Vanderlinden, M P;Butzler, Jean-Paul ;Yourassowsky, Eugène Référence Current medical research and opinion, 5, S2, page (34-37)
Publication Publié, 1978
Article révisé par les pairs
| Résumé : | A clinical and pharmacological evaluation of erythromycin ethylsuccinate was carried out in 20 patients with acute exacerbations of chronic bronchitis. Administration of a 1 g dose after a meal on Day 1 produced serum concentrations of 3.36 μg/ml after 60 min and 3.12 μg/ml after 90 min. Serum levels on Day 4 of treatment with 1 g 4-times daily showed an accumulation of erythromycin, concentrations of over 4 μg/ml being found at 1 to 2 hours after the first dose. Twelve of the 15 patients with microscopic evidence of pus in the sputum and positive for H. influenzae (12) and/or pneumococci (5) showed a satisfactory response to treatment, as did the other 5 patients with negative cultures. In the 3 patients who failed to respond clinically, H. influenzae was still present on culture and the sputum remained purulent. In 2 patients regarded as clinically cured, the sputum was mucoid but H. influenzae persisted. There was no evidence of patient intolerance of treatment with erythromycin ethylsuccinate. © 1978 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
