Cell mediated immunity in diabetes mellitus

Delespesse, Guy; Duchateau, Jean; Bastenie, Paul Auguste

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Cell mediated immunity in diabetes mellitus

par Delespesse, Guy

;Duchateau, Jean

;Bastenie, Paul Auguste

Référence Clinical and experimental immunology, 18, 4, page (461-467)
Publication Publié, 1974

Article révisé par les pairs

Résumé :

The quantitified lymphocyte response to phytohemagglutinin (PHA) was investigated in 56 control subjects, classed according to age and sex, in 29 insulin dependent (IDD) and 8 non insulin dependent diabetics. In 9 cases one way mixed lymphocyte cultures (MLC) were performed using mixed lymphocytes from IDD and paired controls. In the controls, a reduction of the response to PHA was observed with ageing; this was more marked in women than in men. The diabetics gave a greatly impaired response to PHA but only a slightly depressed response in MLC. These anomalies are not influenced by age but by the severity of the diabetes.

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