Article révisé par les pairs
Résumé : This paper reports on a study to investigate in two models of disuse osteoporosis the modification of calcium loss, bone blood flow and calcium clearance. By comparison with their sham-operated controls, it was observed in paraplegia a sustained increase of bone blood flow, a demineralization of the skeleton more pronounced in the trabecular bone of the epiphyse and metaphyse, a clearance of calcium 45 decreased and a temporary stimulation of bone marrow. This particular pattern was not modified by an oral administration of indomethacin. In a model of tibial unloading, a decrease in bone length on the other limb was observed and a diminished bone density and bone calcium load on the unloading side. This model was mainly related to a diminished growth on the overloaded limb.