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Effect of CB 154 (2-Br-α-Ergocryptine) on MXT mammary tumor growth

par Devleeschouwer, Nadine ;Leclercq, Guy ;Heuson, Jean-Claude
Référence IRCS Medical Science, 9, 3, page (199)
Publication Publié, 1981

Article révisé par les pairs

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Résumé :

This work analyses the effect of the potent prolactin secretion inhibitor 2 Br-alpha-ergocryptine (CB 154) on both the acceptance and the growth of the mouse transplantable MXT ovarian-dependent mammary tumor. CB 154 was injected at doses of 25 mg/kg and 50 mg/kg subcutaneously for 10 weeks. This treatment did not decrease the tumor acceptance but delayed the appearance of palpable tumor nodules. Furthermore estimation of the change in tumor surface area (TS) expressed in sq mm revealed that the drug reduced tumor growth. This effect became significant after 8 weeks. Tumor death was also significantly delayed (7 surviving mice in controls versus 13 in the 25 mg/kg group, and 12 in the 50 mg/kg group). The present data suggest that the MXT mouse mammary tumor is sensitive to prolactin. This property associated with the known ovarian hormone sensitivity makes this tumor a valuable experimental model for assessing hormone dependence of mammary carcinomas.