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Empiric therapy for cancer patients: comparative study of ticarcillin tobramycin, ticarcillin cephalothin, and cephalothin tobramycin

par Klastersky, Jean ;Hensgens, Colette;Debusscher, Louise
Référence ANTIMICROB.AGENTS CHEMOTHER., 7, 5, page (640-645)
Publication Publié, 1975

Article révisé par les pairs

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Résumé :

Three combinations of antibiotics (cephalothin tobramycin, cephalothin ticarcillin, and ticarcillin tobramycin) were administered empirically to 186 patients with cancer who were suspected of having a life threatening infection. In approximately one half of these patients, gram negative infection was documented bacteriologically and consisted of septicemia in 50% of these patients. The three antimicrobial regimens were similarly effective and resulted in a favorable clinical response in approximately 55% of the patients. The administration of the cephalothin tobramycin combination was associated with a significantly higher frequency of nephrotoxicity than that of the other two regimens.