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Endotoxin, PAF and arterial thrombosis

par Bourgain, René ;Andries, Roger;Braquet, Pierre
Référence Journal of Lipid Mediators and Cell Signalling, 2, SUPPL., page (S187-S193)
Publication Publié, 1990

Article révisé par les pairs

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Résumé :

Using an optoelectronic device, we demonstrated that endotoxin modulates platelet-activating factor (PAF)-induced arterial thrombosis in a mesenteric artery of the guinea-pig. Indeed, topical superfusion by PAF induces the generation of platelet-vessel wall interactions, invariably followed by thrombus formation. A low dose of endotoxin markedly increased, while a high dose significantly reduced thrombus formation. The reducing effect of the high dose can be completely offset by indometacin, indicating the involvement of prostaglandin I2.