Serum free thyroxine by 'analogue' radioimmunoassays in pregnancy: Unusual binding?

Bourdoux, Pierre; Ermans, André Marie

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Serum free thyroxine by 'analogue' radioimmunoassays in pregnancy: Unusual binding?

par Bourdoux, Pierre

;Ermans, André Marie

Référence Nuc compact, compact news in nuclear medicine, 16, 6, page (363-364)
Publication Publié, 1985

Article révisé par les pairs

Résumé :

The low FT4 values obtained with the Amerlex FT4 'analogue' system in pregnancy can be explained by increases in NEFA. The addition of albumin to serum or to a protein free medium (saline) induces modifications of the bound/total ratio and indicates that the 'analogue' tracer is, at least partly, bound to albumin. The information obtained on the chemical compostion of the Amerlex FT4 tracer suggests a structure like 125l-Thyroxine coupled to albumin. Since the real nature of the binding is still unknown, the results obtained with the analogue systems should be very carefully interpreted.

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