par Couturier, Etienne ;Deleers, Michel ;Malaisse, Willy
Référence Cell calcium, 1, 3, page (171-179)
Publication Publié, 1980
Article révisé par les pairs
Résumé : Sodium inhibits in a dose-related fashion the translocation of calcium from an aqueous milieu into an organic phase containing the divalent-cation ionophore A23187. This inhibitory effect is reproduced by other monovalent cations, modulated by the nature of the anion in the sodium halide, and inversely related to the absolute amount of calcium translocated. The inhibitory effect cannot be attributed to a change in osmolarity or ionic strength, to sequestration of the ionophoretic molecule at the interface between the aqueous and organic phases, or to translocation of sodium or chloride. These findings indicate that sodium may directly affect the handling of calcium by ionophoretic systems specifically mediating the transport of divalent cations. © 1980.