• Citer

Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells.

par Martinet, Valérie ;Tonon, Sandrine ;Torres, David ;Azouz, Abdulkader ;Nguyen, Muriel ;Köhler, Arnaud ;Flamand, Véronique ;Mao, Chai-An;Klein, William WH;Leo, Oberdan ;Goriely, Stanislas
Référence Nature communications, 6, page (7089)
Publication Publié, 2015

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

CD8(+) T-cell memory phenotype and function are acquired after antigen-driven activation. Memory-like cells may also arise in absence of antigenic exposure in the thymus or in the periphery. Eomesodermin (Eomes) is a key transcription factor for the development of these unconventional memory cells. Herein, we show that type I interferon signalling in CD8(+) T cells directly activates Eomes gene expression. Consistent with this observation, the phenotype, function and age-dependent expansion of 'virtual memory' CD8(+) T cells are strongly affected in absence of type I interferon signalling. In addition, type I interferons induce a sustained expansion of 'virtual memory' CD8(+) T cells in an Eomes-dependent fashion. We further show that the development of 'innate thymic' CD8(+) T cells is dependent on the same pathway. In conclusion, we demonstrate that type I interferon signalling in CD8(+) T cells drives Eomes expression and thereby regulates the function and homeostasis of memory-like CD8(+) T cells.