par Soetaert, Karine;Rens, Céline 
;Wang, Xiao-Ming ;De Bruyn, Jacqueline;Laneelle, Marie Antoinette;Laval, Françoise;Lemassu, Anne;Daffe, Mamadou;Bifani, Pablo;Fontaine, Véronique ;Lefèvre, Philippe
Référence Antimicrobial agents and chemotherapy
Publication Publié, 2015-06
;Wang, Xiao-Ming ;De Bruyn, Jacqueline;Laneelle, Marie Antoinette;Laval, Françoise;Lemassu, Anne;Daffe, Mamadou;Bifani, Pablo;Fontaine, Véronique ;Lefèvre, Philippe Référence Antimicrobial agents and chemotherapy
Publication Publié, 2015-06
Article révisé par les pairs
| Résumé : | Mycobacterium tuberculosis is wrapped in complex waxes, impermeable to most antibiotics. Comparing M. bovis BCG and M. tuberculosis mutants, lacking phthiocerol dimycocerosates (PDIM) and/or phenolic glycolipids, with wild-type strains, we observed that glycopeptides strongly inhibited PDIM deprived mycobacteria. Vancomycin together with a drug targeting lipids synthesis inhibited multidrug-resistant (MDR) and extensively-drug resistant (XDR) clinical isolates. Our study puts glycopeptides in the pipeline of potential anti-TB agents and might provide a new antimycobacterial drug-screening strategy. |
