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Both IgG and IgM anti-beta2 glycoprotein i antibodies assays are clinically useful to the antiphospholipid syndrome diagnosis

par Li, R. D.;Daguzan, Marie;Vandermijnsbrugge, Francine;Gyling, M.;Cantinieaux, Brigitte
Référence Acta clinica Belgica (Ed. multilingue), 69, 6, page (433-438)
Publication Publié, 2014-12

Article révisé par les pairs

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Résumé :

Objectives: The aim of our study was to evaluate the clinical values of anti-beta2 glycoprotein I antibodies (anti-beta2GPI) IgG and IgM comparing with lupus anticoagulant (LA), anticardiolipin antibodies (aCL) in the two clinical groups of antiphospholipid syndrome (APS), vascular thrombosis (VT) and pregnancy morbidity (PM). Methods: Eighty patients who fulfilled the APS clinical criteria, VT n534; PM n540, both VT and PM n56 were included. LA, aCL and three anti-beta2GPI ELISA kits were tested. Results: Sensitivities of LA, aCL and anti-beta2GPI assays were found respectively 62, 26 and 41% in VT, and 28, 28 and 30% in PM. The sensitivity for the APS diagnosis could reach to 63% using triple tests. The presence of LA (P,0.01, OR54.3) or anti-beta2GPI IgG alone (P,0.05, OR58.4) was significantly associated with VT. IgM isotype was found more frequent in PM (92%) than in VT (57%) among all positive anti-beta2GPI cases. Conclusion: Both IgG and IgM anti-beta2GPI assays were useful when clinical features of APS presented, even its standardization is ongoing. A decreased by half sensitivity of LA in PM compared with that in VT underlines the importance of adding anti-beta2GPI in PM of APS, especially IgM isotype although recent review questioned its significance.