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Smoking and pulmonary diffusing capacity

par Frans, Albert;Stanescu, Dinu ;Veriter, Claude;Clerbaux, Th;Brasseur, Lucien
Référence Scandinavian Journal of Respiratory Diseases, 56, 3, page (165-183)
Publication Publié, 1975

Article révisé par les pairs

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Résumé :

The pulmonary diffusing capacity (DL (CO SB)) and its two components, the capillary blood volume (Vc) and the diffusing capacity of the membrane (DM (CO)), expressed in absolute values and per liter of alveolar volume (VA'), were measured at rest and on exercise in healthy male smokers and nonsmokers of similar age and height, and with identical values for hemoglobin and spirographic data. DL(CO), DL(CO)/VA', DM(CO) and DM(CO)/VA' are significantly lower in smokers, at rest and on exercise; the decrease in Vc and theta Vc/VA' in smokers at rest is due to a higher level of carboxyhemoglobin. The decrease of DL(CO), DL(CO)/VA', DM(CO) and DM(CO)/VA' is apparently not due to carboxyhemoglobin or distributional factors but to anatomical lesions, probably of emphysematous nature, altering the pulmonary membrane. Formulas predicting DL(CO), DM(CO), Vc, DL(CO)/VA', DM(CO)/VA' and theta Vc/VA' in terms of age and height were established in smokers and in nonsmokers.