Résumé : The post-collisional late Hercynian Tanncherfi intrusive complex (TIC) is part of a widespread intrusive episode in the Moroccan Meseta. The complex contains a wide range of rock types, from monzogabbros to monzogranites. Two distinct magmatic series are recognized: (1) a potassic (shoshonitic) series consisting of monzogabbros, quartz monzonites and monzogranites; and (2) a sodic (granodioritic) series represented by quartz monzodiorites and granodiorites. All the Tanncherfi plutonic rocks display similar spider-diagram profiles, with LILE and LREE enrichment and Nb, Ta, Ti depletion, which are typical of subduction-related magmas. Combined major, trace element compositions and Sr, Nd isotopic results indicate that the two series have been derived from a LILE- and LREE-enriched continental lithospheric mantle source, under different partial melting and/or depth conditions. Intrusion of the Tanncherfi rocks was not temporally related to subduction and the enrichment of their source is likely to be linked to preceding subduction events. The two series evolved by fractional crystallization, of clinopyroxene, plagioclase, hornblende, biotite, K-feldspar and accessories (Fe-Ti oxide minerals, titanite, apatite and zircon) for the potassic series while the sodic series combined fractional crystallization with assimilation of felsic magmas with lower Sr isotopic ratio than the more mafic term of the series, the quartz monzodiorite. The intrusion of the potassic magmas (344 ± 6 Ma) marks a major change in the tectonic regime of eastern Meseta. These magmas intruded during post-thickening uplift and extension, both probably favored by convective thinning of the lithosphere. This model provides a reasonable mechanism for the genesis of other Hercynian intrusive complexes in Morocco.