par Quinto, Ileana;Tenenbaum, Liliane 
;Radman, Miroslaw
Référence Mutation research, 228, 2, page (177-185)
Publication Publié, 1990
;Radman, Miroslaw Référence Mutation research, 228, 2, page (177-185)
Publication Publié, 1990
Article révisé par les pairs
| Résumé : | A quantitative correlation between carcinogeneity and genotoxicity was investigated by a comparison between the carcinogenic potency in rodens and mutagenic (M), recombinogenic (R) and SOS-inducting (I) potencies in a bacterial test (E. coli multitest) for 9 monofunctional alkylating agents: N-methylurethane, N-nitroso-N-ethylrurea, epichlorohydrin, N-nitroso-N-methylurea, N-nitroso-N-methyl-N′- nitroguanidine, methyl methanesulfonate, diethylsulfate, ethyl methanesulfonate. A significant positive correlation between the carcinogenic potency and the product of the mutagenic and recombigenic potencies was found for all tested compounds. Thus, the E. coli multitest may be used as a simple test to search for correlations between carcinogenicity and genotoxicity of DNA-damaging agents. © 1990. |
