par Goldstein, Solo;Neuwels, Michel 
;Culot, Patrick;Differding, Edmond;Dogimont, Charles;van Assche, Yvo;Brichard, M.H. M.H.;Jaspers, Drina;Van Binst, Georges ;Scarso, Alain;Henichart, Jean Pierre
Référence Letters in Peptide Science, 2, 3-4, page (141-146)
Publication Publié, 1995-11
;Culot, Patrick;Differding, Edmond;Dogimont, Charles;van Assche, Yvo;Brichard, M.H. M.H.;Jaspers, Drina;Van Binst, Georges ;Scarso, Alain;Henichart, Jean PierreRéférence Letters in Peptide Science, 2, 3-4, page (141-146)
Publication Publié, 1995-11
Article révisé par les pairs
| Résumé : | A comparative conformational analysis of two short pseudopeptides with ETB receptor affinity has been performed by molecular modelling and NMR techniques. This analysis aimed to get insight into probable biorelevant conformations and pharmacophoric patterns necessary for an efficient interaction with the receptor. Thus, it was shown that the two compounds can adopt γ-turn (or γ-turn-like) conformations, based on which the synthesis of particular, more rigid analogs might be proposed. The results obtained should prove valuable in a strategy aiming to design new endothelin antagonists following a peptide to non-peptide approach. © 1995 ESCOM Science Publishers B.V. |
