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3'-Deoxyadenosine and implantation of delayed blastocysts in mice

par Fernandez-Noval, A.;Leroy, Fernand
Référence Journal of Endocrinology, 81, 3, page (351-354)
Publication Publié, 1979

Article révisé par les pairs

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Résumé :

Pregnant mice were ovariectomized 3 days after mating and pregnancy was maintained by progesterone treatment. Different regimens of intraperitoneal injections of 3'-deoxyadenosine were applied 3 days after ovariectomy. Repetition of the injections at 3 h intervals induced a significant rate of implantation by delayed blastocysts. Other types of treatment with 3'-deoxyadenosine as well as adenosine injections were found to be ineffective. Paradoxically, 3'-deoxyadenosine treatment had an adverse effect on the overall pregnancy rate found at autopsy.