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Resistance to the peptide-like antibiotic negamycin in Escherichia coli

par Corchuelo, Maria Clara;Herzog, Albert ;Desmarez, Liliane;Lavalle, Robert ;Bollen, Alex
Référence Biochemical and biophysical research communications, 100, 4, page (1497-1503)
Publication Publié, 1981-06

Article révisé par les pairs

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Résumé :

An Escherichia coli mutant resistant to the peptide-like antibiotic negamycin carries a mutation, NEG40, which maps at minute 65 on the bacterial genome. Termination of protein synthesis, which is normally blocked by negamycin in wild type cellular extracts, continues with cellular extracts from the mutant in the presence of the drug; indeed, release of complete peptides from the polysomes still proceeds over a wide range of drug concentrations. The data suggest that the NEG40 mutation affects one of the components of the termination complex (ribosome or release factor). © 1981.