par Quenon, Marianne;Henry, P.;Lejeune-Lenain, C. 
;Wolter, Renee Adrienne ;Franckson, Jean
Référence Annales de biologie clinique, 38, 2, page (95-104)
Publication Publié, 1980
;Wolter, Renee Adrienne ;Franckson, Jean Référence Annales de biologie clinique, 38, 2, page (95-104)
Publication Publié, 1980
Article révisé par les pairs
| Résumé : | An improved method of gas-liquid chromatography (GLC) for routine estimation of adrenal steroids in urine is presented. It was applied to the exploration of steroid output in 120 normal prepuberal children to both sexes aged 3 mth to 12 yr. Urinary data were compared to plasmatic values of adrenal hormones estimated by radioimmune assays (RIA). Analysis of the relationships between steroids outputs and bone age revealed that the excretion of cortisol catabolites was expressed by a saturation curve whereas that of Δ 4-3 keto androgens catabolites were expressed by geometrical progression curves; urine dehydroepiandrosterone (DHEA) and plasma DHEA-sulfate showed outbreaks of high values beyond 6 yr of age which ruled out all curve fitting attempts. The computation of these relationships allowed to determine the confidence belts of the various regressions which appear as a useful tool to estimate the delayed or accelerated character of adrenal activity in prepuberal childhood. Comparison of the various urinary (GLC) and plasmatic (RIA) parameters enabled us to comment on adrenal puberty. |
