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The 5th International Symposium on Lateral heterogeneity of the vacuolar membrane during piecemeal microautophagy of the nucleus: Lateral heterogeneity of vacuolar membrane during piecemeal microautophagy of the nucleus

par Dawaliby, Rosie ;Mayer, A.
Référence The 5th International Symposium on Autophagy: Molecular Mechanism, Cellular and Physiological Functions and Diseases(September 24–28, 2009: Otsu Prince Hotel, Otsu, Japan), The 5th International Symposium on Autophagy: Molecular Mechanism, Cellular and Physiological Functions and Diseases, Landes Biosciences, Vol. 5, Ed. 6, page (897)
Publication Publié, 2009-08

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Résumé :

Piecemeal microautophagy of the nucleus (PMN) transfersnuclear material into vacuoles of yeast cells. PMN proceeds inseveral steps including specific recognition between the outernuclear envelope at nuclear-vacuolar (NV) junctions, the invagi-nation of this zone towards the vacuolar lumen and the release ofvesicles from it. We present novel mutants defective in PMN andtheir preliminary assignment to the different phenotypic categoriesindicated above. Furthermore, we discovered a PMN-related differ-entiation of the vacuolar membrane leading to lateral exclusion ofsome vacuolar proteins from NV junctions. These results, togetherwith observations on the exclusion of nuclear pore complexes fromNV junctions,1support the hypothesis that NV junctions areexceptionally tight associations that establish specialized membranezones on both the vacuolar and nuclear sides.